Dependent on alcohol

An alcoholic is someone who has become dependent on alcohol. Though he may never be actually drunk, he becomes progressively poisoned by it, and is physically, mentally and sometimes morally affected. At first, he loses his appetite and feels sick, he grows irritable, disregards his responsibilities, and becomes unpunctual and untruthful. Gradually he loses his sense of adaptability to society, neglects his personal appearance, his judgment is unrealistic and his intellect deteriorates.

disregard 

1) to ignore something or treat it as unimportant

2) when someone ignores something that they should not ignore

total/reckless/complete/flagrant etc disregard

• Please disregard any notes written in the margins. 
• By disregarding speed limits and passing red lights, we somehow got to the airport in time.

disregard for/of

•  his disregard for her feelings
• Local councillors accused the terrorists of showing a complete disregard for human life.

in disregard of something

•  He said the bombing was in complete disregard of the Geneva Convention.

deteriorate

to become worse

• Ethel’s health has deteriorated.
• This state’s deteriorating economy
• Air quality is rapidly deteriorating in our cities.
• Living conditions here have deteriorated in the past few years.

In everyday English, people usually say get worse rather than deteriorate:

• Her health got worse.
• The situation is getting worse.